2. Skin Barrier…
If you have an impaired skin barrier (the layer if your skin that does not allow water and electrolytes to escape your skin), then you are more prone to having itchy skin at night, because all the substances that will make your skin itchy will have access to your skin without any trouble.
These substances are released by your immune system mostly to combat the inflammation that accompanies an allergic reaction.
These substances have the ability to activate the nerve endings on your skin and cause you to feel itchy at night. Keep this in mind, therefore, if you are considering a skin treatment for that itchiness you feel every night.